Quillaja saponaria

Quillaja saponaria, the soap bark tree or soapbark, is an evergreen tree in the family Quillajaceae, native to warm temperate central Chile. In Chile it occurs from 32 to 40° South Latitude approximately and at up to 2000 m (6500 ft) above sea level. It can grow to 15–20 m (50–65 ft) in height. The tree has thick, dark bark; smooth, leathery, shiny, oval evergreen leaves 3–5 cm long; white star-shaped flowers 15 mm in diameter borne in dense corymbs; and a dry fruit with five follicles each containing 10–20 seeds. The tree has several practical and commercial uses.

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The wood is used in cabinetry, and scents derived from the tree are used in perfumes and cosmetics. The inner bark of Quillaja saponaria can be reduced to powder and employed as a substitute for soap, since it forms a lather with water, owing to the presence of a glycoside saponin, sometimes distinguished as quillaia saponin. The same, or a closely similar substance, is found in soapwort (Saponaria officinalis), in senega root (Polygala senega) and in sarsaparilla; it appears to be chemically related to digitonin, which occurs in digitalis. Uses of the saponins Main article: Quillaia Soap bark tree has a long history of medicinal use with the Andean people who used it as a treatment for various chest problems. The saponin content of the bark helps to stimulate the production of a more watery mucus in the airways, thus facilitating the removal of phlegm through coughing. The bark is the source of quillaia, the extract of which is used as a food additive and as an ingredient in pharmaceuticals, pesticides, personal care products, fire-fighting foam, and applied as an agricultural spray adjuvant. It is used as an additive in photographic films and as a foaming agent for drinks. The saponins in Quillaja Extract are also used as the active ingredient in commercial pesticides to inhibit the growth of pathogenic fungi and nematodes in ornamental plants, food crops and turfgrass. The saponins of this tree are also considered to have adjuvant properties for vaccine solutions, and have been used for this purpose since 2017. QS21 adjuvant is a saponin (triterpenoid glycoside) obtainable from Quillaja saponaria extract. The Novavax vaccine for COVID-19 uses this adjuvant, the zoster vaccine Shingrix also contains QS21 as well as the RSV vaccine Arexvy. Toxicity First described by Edwin John Quekett, Q. saponaria wood and bark is known to contain raphides, which George Gulliver found were concentrated along the liber and mesophloeum.

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Quillaja saponaria was originally described in 1782 by Juan Ignacio Molina.

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